09-P002 The transcription co-factor Cited2 functions during sex determination and early gonad development
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09-P002 The transcription co-factor Cited2 functions during sex determination and early gonad development
The apical ectodermal ridge (AER), a thickening of the limb epithelium at its distal tip, is pivotal for maintaining vertebrate limb outgrowth. In a recent study, Flrt3 has been involved in the activation of ERK by FGFs. Moreover, Flrt3 has been described as a transmembrane protein able to interact with FGF receptors modulating, this way, FGFR signaling, either directly or recruiting cytoplasmi...
متن کاملThe transcription co-factor CITED2 functions during sex determination and early gonad development.
The early bi-potential mammalian gonad requires the expression of a Y-linked gene, Sry, during a brief window of time to ensure proper testis development. WT1 and its direct target gene Sf1 function during sex determination as well as in the specified testes and ovaries. We have previously shown that the transcription co-factor CITED2 interacts with WT1 to stimulate the expression of Sf1 in the...
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The development of any organ system requires a complex interplay of cellular signals to initiate the differentiation and development of the heterogeneous cell and tissue types required to carry out the organs' functions. In this way, an extracellular stimulus is transmitted to an intracellular target through an array of interacting protein intermediaries, ultimately enabling the target cell to ...
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The formation of testes or ovaries in the mammalian embryo is critical in determining sexual identity and the ability to reproduce. Recent studies have begun to illuminate the cellular signalling events required for development of functional testes.
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Noggin1 is a famous embryonic neural inducer that can sequester TGF-beta cytokines of Bone Morphogenetic Protein family, thereby antagonizing Smad1-dependent signaling pathway activity. During early embryogenesis noggin1 executes two major biological functions: conversion of embryonic mesoderm into skeletal muscles (dorsalization) and of ectoderm into neural tissue (neuralization). Anterior neu...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2009
ISSN: 0925-4773
DOI: 10.1016/j.mod.2009.06.332